Hodgkin lymphoma in patient with primary immunodeficiency: clinical features and treatment approaches

Primary immunodeficiencies (PID) are genetically determined irreversible disorders of structure and/or functions the immune system's cellular and humoral components, accompanied by frequent infectious diseases contributing to development malignant neoplasms. Lymphomas most oncological disease in PID patients: non-Hodgkin's lymphomas occur 60 % neoplasms cases, Hodgkin lymphoma - 20 %, leukemias 10 solid tumors %. The risk lymphoproliferative patients amounts 4-25 with overall incidence cancer 100-200 times higher than immunocompetent population. Results treatment children remain unsatisfactory due high rate relapsed, refractory anticancer therapy complications. This paper presents a clinical case atypical localization female patient. peculiarities this eye socket soft tissue involvement, slow response therapy,